Invention Grant
US09321848B2 Method for preventing the unfolding of a (poly)peptide and/or inducing the (re-)folding of a (poly)peptide
有权
防止（多）肽展开和/或诱导（重复）（多）肽折叠的方法
- Patent Title: Method for preventing the unfolding of a (poly)peptide and/or inducing the (re-)folding of a (poly)peptide
- Patent Title (中): 防止（多）肽展开和/或诱导（重复）（多）肽折叠的方法
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Application No.: US14123168Application Date: 2012-06-28
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Publication No.: US09321848B2Publication Date: 2016-04-26
- Inventor: Martin Scholz , Jens Altrichter , Kristina Kemter
- Applicant: Martin Scholz , Jens Altrichter , Kristina Kemter
- Applicant Address: DE Munich
- Assignee: LEUKOCARE AG
- Current Assignee: LEUKOCARE AG
- Current Assignee Address: DE Munich
- Agency: Gavrilovich, Dodd & Lindsey, LLP
- Agent Joseph R. Baker, Jr.
- Priority: EP11005280 20110628; EP11009019 20111114
- International Application: PCT/EP2012/062645 WO 20120628
- International Announcement: WO2013/001044 WO 20130103
- Main IPC: C07K1/06
- IPC: C07K1/06 ; C07K17/00 ; A61K9/19 ; A61K47/18 ; C07K1/113 ; A61K9/08 ; A61K39/395 ; C07K16/24 ; C07K16/32 ; C12N7/00 ; C12N9/04 ; C12N9/96
Abstract:
The present invention relates to a method for preventing the unfolding of a (poly)peptide during drying and/or inducing the (re-)folding of a (poly)peptide after drying, comprising the step of embedding the (poly)peptide in an aqueous solution, wherein the solution comprises (i) at least three different amino acids; or (ii) at least one dipeptide or tripeptide; and wherein the solution is free or substantially free of (a) sugar; and (b-i) protein; and/or (b-ii) denaturing compounds; and (c) silanes.
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