Invention Grant
US09321993B2 Tissue culture method for producing cartilage using trimethylamine N-oxide and chondroitinase
有权
使用三甲胺N-氧化物和软骨素酶生产软骨的组织培养方法
- Patent Title: Tissue culture method for producing cartilage using trimethylamine N-oxide and chondroitinase
- Patent Title (中): 使用三甲胺N-氧化物和软骨素酶生产软骨的组织培养方法
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Application No.: US13704839Application Date: 2011-06-17
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Publication No.: US09321993B2Publication Date: 2016-04-26
- Inventor: Clark T. Hung , Grace D. O'Connell
- Applicant: Clark T. Hung , Grace D. O'Connell
- Applicant Address: US NY New York
- Assignee: The Trustees of Columbia University in the City of New York
- Current Assignee: The Trustees of Columbia University in the City of New York
- Current Assignee Address: US NY New York
- Agency: Dentons US LLP
- International Application: PCT/US2011/040875 WO 20110617
- International Announcement: WO2011/160012 WO 20111222
- Main IPC: C12N5/00
- IPC: C12N5/00 ; C12N5/077 ; A61K35/32
Abstract:
The present disclosure provides cell culture medium comprising trimethylamine N-oxide (TMAO). Progenitor cells cultured with such medium can form connective tissue with enhanced mechanical properties. Also provided are methods of forming connective tissue and methods of treatment for connective tissue defects.
Public/Granted literature
- US20130202567A1 TISSUE CULTURE MEDIA CONTAINING TRIMETHYLAMINE N-OXIDE Public/Granted day:2013-08-08
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