Invention Grant
US09322018B2 Angiopoietin-like 3 (ANGPTL3) iRNA compositions and methods of use thereof
有权
促血管生成素样3（ANGPTL3）iRNA组合物及其使用方法
- Patent Title: Angiopoietin-like 3 (ANGPTL3) iRNA compositions and methods of use thereof
- Patent Title (中): 促血管生成素样3（ANGPTL3）iRNA组合物及其使用方法
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Application No.: US14132999Application Date: 2013-12-18
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Publication No.: US09322018B2Publication Date: 2016-04-26
- Inventor: Brian Bettencourt , William Querbes , Kevin Fitzgerald , Maria Frank-Kamenetsky , Stuart Milstein , Svetlana Shulga Morskaya
- Applicant: Alnylam Pharmaceuticals, Inc.
- Applicant Address: US MA Cambridge
- Assignee: Alnylam Pharmaceuticals, Inc.
- Current Assignee: Alnylam Pharmaceuticals, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: McCarter & English, LLP
- Agent Maria Laccotripe Zacharakis; Deborah L. Nagle
- Main IPC: A61K31/70
- IPC: A61K31/70 ; C07H21/02 ; C07H21/04 ; C12N15/113 ; A61K31/713 ; A61K31/7105 ; C12Q1/68
Abstract:
The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the ANGPTL3 gene, as well as methods of inhibiting expression of ANGPTL3 and methods of treating subjects having a disorder of lipid metabolism, such as hyperlipidemia or hypertriglyceridemia, using such dsRNA compositions.
Public/Granted literature
- US20140179768A1 ANGIOPOIETIN-LIKE 3 (ANGPTL3) iRNA COMPOSITIONS AND METHODS OF USE THEREOF Public/Granted day:2014-06-26
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