Invention Grant
- Patent Title: Oligomers
- Patent Title (中): 低聚物
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Application No.: US14504453Application Date: 2014-10-02
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Publication No.: US09322019B2Publication Date: 2016-04-26
- Inventor: John George Dickson , Jagjeet Kaur Kang
- Applicant: Royal Holloway and Bedford New College
- Applicant Address: GB Surrey
- Assignee: Royal Holloway and Bedford New College
- Current Assignee: Royal Holloway and Bedford New College
- Current Assignee Address: GB Surrey
- Agency: Banner & Witcoff, Ltd.
- Main IPC: C07H21/04
- IPC: C07H21/04 ; C12N15/113 ; A61K47/48

Abstract:
Certain disclosed oligomers induce exon skipping during processing of myostatin pre-mRNA. The oligomers may be in a vector or encoded by the vector. The vector is used for inducing exon skipping during processing of myostatin pre-mRNA. A therapeutically effective amount of the oligomer may be administered to a subject patient such that exon skipping during processing of myostatin pre-mRNA is induced. The administration to a subject may be used in order to increase or maintain muscle mass, or slowing degeneration of muscle mass in the subject. The administration to a subject may ameliorate muscle wasting conditions, such as muscular dystrophy. Examples of such muscular dystrophies which may be so treated include Becker's muscular dystrophy, congenital muscular dystrophy, Duchenne muscular dystrophy, distal muscular dystrophy, Emery-Dreifuss muscular dystrophy, facioscapulohumeral muscular dystrophy (FSHD), limb-girdle muscular dystrophy, myotonic muscular dystrophy, and oculopharyngeal muscular dystrophy.
Public/Granted literature
- US20150045415A1 Oligomers Public/Granted day:2015-02-12
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