Invention Grant
US09322020B2 RNA interference mediated inhibition of isocitrate dehydrogenase (IDH1) gene expression
有权
RNA干扰介导的异柠檬酸脱氢酶（IDH1）基因表达的抑制
- Patent Title: RNA interference mediated inhibition of isocitrate dehydrogenase (IDH1) gene expression
- Patent Title (中): RNA干扰介导的异柠檬酸脱氢酶（IDH1）基因表达的抑制
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Application No.: US14123822Application Date: 2012-06-01
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Publication No.: US09322020B2Publication Date: 2016-04-26
- Inventor: Yong Ma , Duncan Brown , Steven Bartz
- Applicant: Yong Ma , Duncan Brown , Steven Bartz
- Applicant Address: US MA Cambridge
- Assignee: Sirna Therapeutics, Inc.
- Current Assignee: Sirna Therapeutics, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: McCarter & English, LLP
- Agent Maria Laccotripe Zacharakis; Deborah L. Nagle
- International Application: PCT/US2012/040332 WO 20120601
- International Announcement: WO2012/170284 WO 20121213
- Main IPC: C12N15/113
- IPC: C12N15/113 ; C07H21/02
Abstract:
The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of IDH1 and mutant IDH1 gene expression and/or activity, and/or modulate an IDH1 or mutant IDH1 gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules, including small nucleic acid molecules such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules, that are capable of mediating or that mediate RNA interference (RNAi) against IDH1 or mutant IDH1 gene expression.
Public/Granted literature
- US20140094503A1 RNA INTERFERENCE MEDIATED INHIBITION OF ISOCITRATE DEHYDROGENASE (IDH1) GENE EXPRESSION Public/Granted day:2014-04-03
Information query
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