Invention Grant
US09322065B2 Methods for determining methylation of the TWIST1 gene for bladder cancer detection
有权
用于确定膀胱癌检测的TWIST1基因甲基化的方法
- Patent Title: Methods for determining methylation of the TWIST1 gene for bladder cancer detection
- Patent Title (中): 用于确定膀胱癌检测的TWIST1基因甲基化的方法
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Application No.: US12678696Application Date: 2008-09-11
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Publication No.: US09322065B2Publication Date: 2016-04-26
- Inventor: Isabelle Renard , Wim Van Criekinge
- Applicant: Isabelle Renard , Wim Van Criekinge
- Applicant Address: BE Herstal
- Assignee: MDxHealth SA
- Current Assignee: MDxHealth SA
- Current Assignee Address: BE Herstal
- Agency: Andrus Intellectual Property Law, LLP
- Priority: GBPCT/GB2008/002093 20080619
- International Application: PCT/EP2008/007465 WO 20080911
- International Announcement: WO2009/036922 WO 20090326
- Main IPC: C12Q1/68
- IPC: C12Q1/68
Abstract:
Disclosed are methods of detecting a predisposition to, or the incidence of, bladder cancer in a sample comprising detecting an epigenetic change, such as methylation, in at least one gene selected from TWIST1, NID2, RUNX3, BMP7, CCNA1, PDLIM4, TNFRSF25, APC, RASSF1A, LOXL1, TUBB4, NTRK2, ARFGAP3, OSMR and TJP2, or a panel thereof. Also disclosed are kits for performing the disclosed methods, such as kits for detecting a predisposition to, or the incidence of, bladder cancer in a sample comprising at least one primer pair for determining the methylation status of each of NID2, TWIST1 and RUNX3. The kits may contain means for processing a urine sample.
Public/Granted literature
- US20100280134A1 Markers for Bladder Cancer Detection Public/Granted day:2010-11-04
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