A latch assembly includes a door latch member and a release member. The door latch member pivots between a latched position and an unlatched position. The release member is movably coupled to the door latch member to move the door latch member from the latched position to the unlatched position. An inertia activated lock-out mechanism includes a locking member and a counterweight. The locking member moves between a locking position that prevents movement of the door latch member from the latched position to the unlatched position, and a non-interfering position in which the door latch member operates between the latched position and the unlatched position. The counterweight moves the locking member to the locking position in response to an inertial force exceeding a threshold level being applied to the vehicle door latch mechanism.