A firearm with replaceable grip in one embodiment includes a grip frame, a grip, and a rotary camlock mechanism configured to lock and unlock the grip from the grip frame. The camlock mechanism may be rotated between locked and unlocked positions preventing or enabling removal of the grip from the grip frame. In one embodiment, the camlock mechanism includes a movable blocking surface engageable with the grip to block its removal. The camlock mechanism in one configuration may comprise a rotatable locking cam that defines the blocking surface. A camtrack may be provided to convert rotary motion of the cam into linear displacement relative to the grip frame for selectively projecting or retracting the blocking surface relative to the frame.