Invention Grant
US09322825B2 Modified anti-heparin/PF4 complex antibody and HIT antibody standard
有权
改良的抗肝素/ PF4复合抗体和HIT抗体标准
- Patent Title: Modified anti-heparin/PF4 complex antibody and HIT antibody standard
- Patent Title (中): 改良的抗肝素/ PF4复合抗体和HIT抗体标准
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Application No.: US13061072Application Date: 2009-08-26
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Publication No.: US09322825B2Publication Date: 2016-04-26
- Inventor: Nobuhiro Hoshino
- Applicant: Nobuhiro Hoshino
- Applicant Address: JP Tokyo
- Assignee: LSI MEDIENCE CORPORATION
- Current Assignee: LSI MEDIENCE CORPORATION
- Current Assignee Address: JP Tokyo
- Agency: Kilpatrick Townsend & Stockton LLP
- Priority: JP2008-218801 20080827
- International Application: PCT/JP2009/064828 WO 20090826
- International Announcement: WO2010/024271 WO 20100304
- Main IPC: G01N33/564
- IPC: G01N33/564 ; C07K16/18 ; C07K16/24 ; G01N33/531 ; C07K16/36 ; C07K16/44
Abstract:
Provided is a modified antibody which enables the quantitative measurement of the amount of a heparin/PF4 complex, an onset factor of heparin-induced trombocytopenia (HIT), without the influence of the presence of PF4, and which can be used as an HIT antibody standard specific for the heparin/PF4 complex. The modified antibody is prepared by linking a human IgG, or an antibody fragment derived from a human IgG, to a monoclonal antibody obtained by immunizing an animal (excluding a human) with the heparin/PF4 complex.
Public/Granted literature
- US20110171753A1 MODIFIED ANTI-HEPARIN/PF4 COMPLEX ANTIBODY AND HIT ANTIBODY STANDARD Public/Granted day:2011-07-14
Information query
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