A mobile device may include a digital data driver and digital data receiver for communication of digital signals within the mobile device at a selected clock rate. The mobile device may also have a device external for the digital data driver and digital data receiver for communication of external signals, such as radio-frequency signals, to and from the mobile device. To avoid interference of frequency harmonics of a digital signal with such external signals, the digital data driver may be configured to control the digital signal based on the frequency of the external signals, such that interference of the external signal by spectral content of the digital signal is minimized, while maintaining the selected clock rate.