A method and base station (600) of a first cell (602), for—controlling inter-cell interference in a cellular network when Discontinuous Reception, DRX, is applied for User Equipments, UEs. The base station selects a DRX scheme with active periods that are separated in time from active periods of a DRX scheme used for UEs in DRX mode in a neighboring second cell (806). The selected DRX scheme is then used for a first UE (604) in DRX mode in the first cell to avoid interference between transmissions of signals in the active periods to the first UE in the first cell and transmissions of signals in active periods to the UEs in the neighboring second cell.