A method and system for optimizing network I/O throughput is disclosed. In one embodiment, a method for optimizing an input/output (I/O) throughput for a storage network comprises measuring a service time for a storage device of the storage network in completing an I/O request serviced by a storage driver. The method also comprises determining a status of an I/O performance between the storage driver and the storage device by comparing the service time with an expected service time for the storage device in completing the I/O request, where the expected service time is calculated based on a type of the storage device and a size of the I/O request. The method further comprises adjusting a maximum queue depth associated with the storage device based on the status of the I/O performance.