A panel for ventilation and noise reduction and its manufacturing method are disclosed. A left side and a right side of the panel each include one or a plurality of ventilation holes, and a sound insulation board for sound insulation is set near each ventilation hole along an inner side of the panel, so that at least certain sound from the inner of the electronic device needs to bypass the board to pass through the ventilation holes; and the ventilation hole on the left side and the right side of the panel are opened in a staggered position, so that when the panel is placed side by side with another panel, air exhausted from a ventilation hole at an adjacent side of the panel does not form strong face-to-face blowing interference with air exhausted from a ventilation hole at an adjacent side of another panel.