Invention Grant
- Patent Title: Self-assembling nanoparticles composed of transmembrane peptides and their application for specific intra-tumor delivery of anti-cancer drugs
- Patent Title (中): 由跨膜肽构成的自组装纳米颗粒及其用于特异性肿瘤内递送抗癌药物的应用
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Application No.: US12513950Application Date: 2007-11-06
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Publication No.: US09326950B2Publication Date: 2016-05-03
- Inventor: Nadya I. Tarasova , Sergey G. Tarasov , Christopher J. Michejda
- Applicant: Nadya I. Tarasova , Sergey G. Tarasov , Christopher J. Michejda , Maria J. Michejda
- Applicant Address: US DC Washington
- Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee Address: US DC Washington
- Agency: Leydig, Voit & Mayer
- International Application: PCT/US2007/083772 WO 20071106
- International Announcement: WO2008/058125 WO 20080515
- Main IPC: A61K9/51
- IPC: A61K9/51
Abstract:
The invention provides a method of handling a hydrophobic agent, which method comprises (a) combining in an aqueous solution (i) a hydrophobic agent and (ii) an isolated peptide that is a structural analog of a transmembrane domain of an integral membrane protein, wherein one terminus of the peptide has one or more negatively charged residues, and (b) allowing the peptide to self-assemble into nanoparticles, wherein the nanoparticles comprise the hydrophobic agent.
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