Invention Grant
- Patent Title: A3 adenosine receptor allosteric modulators
- Patent Title (中): A3腺苷受体变构调节剂
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Application No.: US13800560Application Date: 2013-03-13
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Publication No.: US09326978B2Publication Date: 2016-05-03
- Inventor: Anikó Göblyös , Johannes Brussee , Adriaan P. Ijzerman , Zhan-Guo Gao , Kenneth Jacobson
- Applicant: Anikó Göblyös , Johannes Brussee , Adriaan P. Ijzerman , Zhan-Guo Gao , Kenneth Jacobson
- Applicant Address: US DC Washington NL Leiden
- Assignee: The United States of America, Represented by the Secretary, Dept. of Health and Human Services,Universiteit Leiden
- Current Assignee: The United States of America, Represented by the Secretary, Dept. of Health and Human Services,Universiteit Leiden
- Current Assignee Address: US DC Washington NL Leiden
- Agency: Vorys, Sater, Seymour and Pease LLP
- Main IPC: A61K31/4745
- IPC: A61K31/4745 ; A61K31/00 ; C07D471/04
Abstract:
The claimed subject matter relates to allosteric modulation of A3 adenosine receptor (A3AR) and provides for the use of an A3 adenosine receptor modulator (A3RM), for the preparation of pharmaceutical compositions for modulating the A3AR in a subject, as well as pharmaceutical compositions including the same and therapeutic methods including administering to a subject an amount of an A3RM, the amount being effective to modulate A3AR activity. The A3RM according to claimed subject matter are 1H-Imidazo-[4,5-c]quinolin-4-amine derivatives. Also provided are 1H-Imidazo-[4,5-c]quinolin-4-amine derivatives.
Public/Granted literature
- US20130197025A1 A3 ADENOSINE RECEPTOR ALLOSTERIC MODULATORS Public/Granted day:2013-08-01
Information query
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