Invention Grant
US09326992B2 Methods for treating progeroid laminopathies using oligonucleotide analogues targeting human LMNA
有权
使用针对人LMNA的寡核苷酸类似物治疗progeroid laminopathies的方法
- Patent Title: Methods for treating progeroid laminopathies using oligonucleotide analogues targeting human LMNA
- Patent Title (中): 使用针对人LMNA的寡核苷酸类似物治疗progeroid laminopathies的方法
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Application No.: US13708709Application Date: 2012-12-07
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Publication No.: US09326992B2Publication Date: 2016-05-03
- Inventor: Ryszard Kole , Francis S. Collins , Michael R. Erdos , Kan Cao
- Applicant: Sarepta Therapeutics, Inc. , The United States of America, as represented by the Secretary, Department of Health and Human Services , University of Maryland
- Applicant Address: US OR Corvallis US DC Washington US MD College Park
- Assignee: Sarepta Therapeutics, Inc.,The United States of America, as represented by the Secretary, Department of Health and Human Services,University of Maryland
- Current Assignee: Sarepta Therapeutics, Inc.,The United States of America, as represented by the Secretary, Department of Health and Human Services,University of Maryland
- Current Assignee Address: US OR Corvallis US DC Washington US MD College Park
- Agency: Seed IP Law Group PLLC
- Main IPC: C12N15/113
- IPC: C12N15/113 ; A61K31/713 ; C12N15/11
Abstract:
Provided are methods of treatment in subjects having progeroid diseases and related conditions which rely upon LMNA-targeted antisense oligonucleotides for reducing expression of one or more aberrantly spliced LMNA mRNA isoforms that encode progerin.
Public/Granted literature
- US20140024698A1 METHODS FOR TREATING PROGEROID LAMINOPATHIES USING OLIGONUCLEOTIDE ANALOGUES TARGETING HUMAN LMNA Public/Granted day:2014-01-23
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