Provided is a fixation device for retaining a skin penetrating medical device, such as a cannula, on the skin of a patient. The fixation device includes a retaining component including a support layer having an adhesive coating, and a landing zone component, including a support layer having an adhesive coating, the landing zone component being adapted to be adhesively attached to the skin around the point of penetration. The retaining component acts as a skin-contacting component and is adapted to be applied on top of the landing zone component, and at least partially cover the medical device, such that the adhesive coating of the retaining component is applied to the support layer of the landing zone component. The adhesive coating of the retaining component includes a first adhesive, and the adhesive coating of the landing zone component includes a second adhesive, the first adhesive being different from the second adhesive.