There is provided a honeycomb-shaped ceramic separation-membrane structure having higher pressure resistance than conventional ones and being capable of reducing production costs. The honeycomb-shaped ceramic separation-membrane structure is provided with a honeycomb-shaped base material, an intermediate layer, and a separation layer. At least part of a ceramic porous body has a structure where aggregate particles are bonded to one another by an inorganic bonding material component. In the ceramic separation-membrane structure, an internal pressure fracture strength capable of fracturing the structure by application of water pressure inside the cells is 7 MPa or more.