A synthetic bead for use in mineral separation is described. The synthetic bead has a surface made of or coated with a synthetic material such as a polymer that is naturally hydrophobic or a polymer that is hydrophobically modified. The synthetic bead can be made of glass having a coating or polysiloxane. The synthetic beads can be placed in flotation cell containing a mixture of water, collector molecules, valuable material and unwanted material or in a pipeline where the mixture is transported from one location to another. The collector chemical can be xanthates. The enriched synthetic beads carrying the mineral particles are separated from the unwanted materials in the mixture. The mineral particles are then released from the synthetic beads by means of low pH treatment, ultrasonic agitation, thermal or electromagnetic treatment.