Invention Grant
US09328066B2 Chiral synthesis of N-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-methoxyphenyl}-1-[2,3-dihydroxy-propyl]cyclopropanesulfonamides
有权
手性合成N- {3,4-二氟-2 - [（2-氟-4-碘苯基）氨基] -6-甲氧基苯基} -1- [2,3-二羟基 - 丙基]环丙烷磺酰胺
![Chiral synthesis of N-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-methoxyphenyl}-1-[2,3-dihydroxy-propyl]cyclopropanesulfonamides](/docs/US/2016-05-03/US09328066B2/abs.jpg.600x600.jpg)
- Patent Title: Chiral synthesis of N-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-methoxyphenyl}-1-[2,3-dihydroxy-propyl]cyclopropanesulfonamides
- Patent Title (中): 手性合成N- {3,4-二氟-2 - [（2-氟-4-碘苯基）氨基] -6-甲氧基苯基} -1- [2,3-二羟基 - 丙基]环丙烷磺酰胺
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Application No.: US14122568Application Date: 2012-05-24
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Publication No.: US09328066B2Publication Date: 2016-05-03
- Inventor: Peter Fey , Agathe Christine Mayer
- Applicant: Peter Fey , Agathe Christine Mayer
- Applicant Address: DE Monheim
- Assignee: BAYER INTELLECTUAL PROPERTY GMBH
- Current Assignee: BAYER INTELLECTUAL PROPERTY GMBH
- Current Assignee Address: DE Monheim
- Priority: EP11167806 20110527
- International Application: PCT/EP2012/059717 WO 20120524
- International Announcement: WO2012/163799 WO 20121206
- Main IPC: C07C211/43
- IPC: C07C211/43 ; C07D317/10 ; C07C303/38 ; C07C303/40 ; C07C309/71 ; C07D309/12 ; C07D317/18 ; C07F7/18 ; C07D303/34 ; C07D317/24
![Chiral synthesis of N-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-methoxyphenyl}-1-[2,3-dihydroxy-propyl]cyclopropanesulfonamides](/abs-image/US/2016/05/03/US09328066B2/abs.jpg.150x150.jpg)
Abstract:
The present invention relates to a novel enantioselective method of preparing (S)- and (R)-enantiomers of N-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-5 methoxyphenyl}-1-[2,3-dihydroxy-propyl]cyclopropanesulfonamide, to novel intermediate compounds, and to the use of said novel intermediate compounds for the preparation of said (S)- and (R)-enantiomers of N-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-methoxyphenyl}-1-[2,3-dihydroxy-propyl]cyclopropanesulfonamide.
Public/Granted literature
- US20140155637A1 CHIRAL SYNTHESIS OF N--1-[2,3-DIHYDROXY-PROPYL]CYCLOPROPANESULFONAMIDES Public/Granted day:2014-06-05
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