Invention Grant
- Patent Title: Aryl-and heteroarylcarbonyl derivatives of hexahydroindenopyridine and octahydrobenzoquinoline
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Application No.: US13922889Application Date: 2013-06-20
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Publication No.: US09328072B2Publication Date: 2016-05-03
- Inventor: Matthias Eckhardt , Frank Himmelsbach , Linghang Zhuang , Stefan Peters
- Applicant: Matthias Eckhardt , Frank Himmelsbach , Linghang Zhuang , Stefan Peters
- Applicant Address: US PA Fort Washington DE Ingelheim am Rhein
- Assignee: Vitae Pharmaceuticals, Inc.,Boehringer Ingelheim International GmbH
- Current Assignee: Vitae Pharmaceuticals, Inc.,Boehringer Ingelheim International GmbH
- Current Assignee Address: US PA Fort Washington DE Ingelheim am Rhein
- Agency: McCarter & English, LLP
- Agent Steven G. Davis; Michael J. DeGrazia
- Priority: EP09175233 20091106
- Main IPC: C07D401/06
- IPC: C07D401/06 ; C07D417/06 ; C07D413/14 ; C07D221/06 ; C07D471/04 ; C07D221/10 ; C07D401/12 ; C07D401/14 ; C07D405/14 ; C07D498/04
Abstract:
The present invention relates to compounds defined by formula I wherein the variables R1, R2, R3, R4, and m are defined as in claim 1, possessing valuable pharmacological activity. Particularly, the compounds are inhibitors of 11β-hydroxysteroid dehydrogenase (HSD) 1 and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme, such as metabolic diseases, in particular diabetes type 2, obesity, and dyslipidemia.
Public/Granted literature
- US20140031544A1 ARYL-AND HETEROARYLCARBONYL DERIVATIVES OF HEXAHYDROINDENOPYRIDINE AND OCTAHYDROBENZOQUINOLINE Public/Granted day:2014-01-30
Information query
