Invention Grant
US09328083B2 2-aminated methylene or 2-esterified methylene tanshinone derivatives, and preparation method and application thereof
有权
2-氨基亚甲基或2-酯化亚甲基丹参酮衍生物及其制备方法和应用
- Patent Title: 2-aminated methylene or 2-esterified methylene tanshinone derivatives, and preparation method and application thereof
- Patent Title (中): 2-氨基亚甲基或2-酯化亚甲基丹参酮衍生物及其制备方法和应用
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Application No.: US14361548Application Date: 2012-11-30
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Publication No.: US09328083B2Publication Date: 2016-05-03
- Inventor: Rongzhen Xu , Frank Rong , Fuwen Xie , Hongxi Lai
- Applicant: HANGZHOU BENSHENG PHARMACEUTICAL CO., LTD.
- Applicant Address: CN Hangzhou
- Assignee: HANGZHOU BENSHENG PHARMACEUTICAL CO., LTD.
- Current Assignee: HANGZHOU BENSHENG PHARMACEUTICAL CO., LTD.
- Current Assignee Address: CN Hangzhou
- Agency: Lathrop & Gage LLP
- Agent Brian C. Trinque; Benjamin D. Heuberger
- Priority: WOPCT/CN2011/083261 20111130
- International Application: PCT/CN2012/085660 WO 20121130
- International Announcement: WO2013/079022 WO 20130606
- Main IPC: C07D307/77
- IPC: C07D307/77 ; C07D405/12
Abstract:
The present invention belongs to the field of natural medicine and pharmaceutical chemistry, and specifically relates to novel 2-aminated methylene or 2-esterified methylene tanshinone I derivatives of formula (I) or a pharmaceutically acceptable salt thereof, to a process for the preparation of these compounds, compositions containing such compounds and their use in preparing antineoplastic medicaments. When X is nitrogen, formula I indicates 2-aminated methylene tanshinone I; when X is oxygen, formula I indicates 2-esterified methylene tanshinone I.
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