Invention Grant
- Patent Title: Heterocyclic compounds and expansion agents for hematopoietic stem cells
- Patent Title (中): 造血干细胞的杂环化合物和扩增剂
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Application No.: US13875387Application Date: 2013-05-02
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Publication No.: US09328085B2Publication Date: 2016-05-03
- Inventor: Taito Nishino , Shunsuke Iwamoto , Katsuaki Miyaji
- Applicant: NISSAN CHEMICAL INDUSTRIES, LTD.
- Applicant Address: JP Tokyo
- Assignee: Nissan Chemical Industries, Ltd.
- Current Assignee: Nissan Chemical Industries, Ltd.
- Current Assignee Address: JP Tokyo
- Agency: Oblon, McClelland, Maier & Neustadt, L.L.P.
- Priority: JP2009-135495 20090604
- Main IPC: C12N5/00
- IPC: C12N5/00 ; C07D333/32 ; C07D333/38 ; C07D409/12 ; C07D409/14 ; C12N5/0789

Abstract:
An expansion agent for hematopoietic stem cells and/or hematopoietic progenitor cells useful for improvement in the efficiency of gene transfer into hematopoietic stem cells for gene therapy useful for treatment of various disorders is provided. An expansion agent for hematopoietic stem cells and/or hematopoietic progenitor cells is provided, containing a compound represented by the formula (I): (wherein X, Y, Z, Ar1 , R1, R2, R3, R4, R5, R6 and R7 are as defined in the description), a tautomer, amide, ester, or pharmaceutically acceptable salt of the compound or a solvate thereof, which can expand hematopoietic stem cells and/or hematopoietic progenitor cells.
Public/Granted literature
- US20130245255A1 HETEROCYCLIC COMPOUNDS AND EXPANSION AGENTS FOR HEMATOPOIETIC STEM CELLS Public/Granted day:2013-09-19
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