Invention Grant
US09328111B2 Substituted cycloocta[5,6]pyrido[4,3,2-de]phthalazines as PARP inhibitors
有权
取代的环辛[5,6]吡啶并[4,3,2-de]酞嗪作为PARP抑制剂
![Substituted cycloocta[5,6]pyrido[4,3,2-de]phthalazines as PARP inhibitors](/docs/US/2016-05-03/US09328111B2/abs.jpg.600x600.jpg)
- Patent Title: Substituted cycloocta[5,6]pyrido[4,3,2-de]phthalazines as PARP inhibitors
- Patent Title (中): 取代的环辛[5,6]吡啶并[4,3,2-de]酞嗪作为PARP抑制剂
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Application No.: US14369388Application Date: 2011-12-31
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Publication No.: US09328111B2Publication Date: 2016-05-03
- Inventor: Changyou Zhou , Bo Ren , Hexiang Wang
- Applicant: Changyou Zhou , Bo Ren , Hexiang Wang
- Applicant Address: KY Grand Cayman
- Assignee: BeiGene Ltd.
- Current Assignee: BeiGene Ltd.
- Current Assignee Address: KY Grand Cayman
- Agency: Cooley, LLP
- International Application: PCT/CN2011/085155 WO 20111231
- International Announcement: WO2013/097226 WO 20130704
- Main IPC: A61K31/5025
- IPC: A61K31/5025 ; C07D237/26 ; C07D471/14 ; C07D471/06 ; C07D471/16 ; C07D471/04
![Substituted cycloocta[5,6]pyrido[4,3,2-de]phthalazines as PARP inhibitors](/abs-image/US/2016/05/03/US09328111B2/abs.jpg.150x150.jpg)
Abstract:
The present invention provides a compound of Formula (I): wherein the variables Z, n, Y and p are as defined herein, and pharmaceutically acceptable salts thereof, which can inhibit the activity of poly (ADP-ribose)polymerases, and pharmaceutical compositions comprising the same.
Public/Granted literature
- US20150018356A1 FUSED TETRA OR PENTA-CYCLIC PYRIDOPHTHALAZINONES AS PARP INHIBITORS Public/Granted day:2015-01-15
Information query
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