Invention Grant
US09328120B2 6-cycloalkyl-pyrazolopyrimidinones for the treatment of CNS disorders
有权
6-环烷基 - 吡唑并嘧啶酮用于治疗CNS疾病
- Patent Title: 6-cycloalkyl-pyrazolopyrimidinones for the treatment of CNS disorders
- Patent Title (中): 6-环烷基 - 吡唑并嘧啶酮用于治疗CNS疾病
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Application No.: US14511238Application Date: 2014-10-10
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Publication No.: US09328120B2Publication Date: 2016-05-03
- Inventor: Niklas Heine , Christian Eickmeier , Marco Ferrera , Riccardo Giovannini , Holger Rosenbrock , Gerhard Schaenzle
- Applicant: Niklas Heine , Christian Eickmeier , Marco Ferrera , Riccardo Giovannini , Holger Rosenbrock , Gerhard Schaenzle
- Applicant Address: DE Ingelheim am Rhein
- Assignee: Boehringer Ingelheim International GmbH
- Current Assignee: Boehringer Ingelheim International GmbH
- Current Assignee Address: DE Ingelheim am Rhein
- Agent Michael P. Morris; Edward S. Lazer
- Priority: EP10172597 20100812; EP11154397 20110214
- Main IPC: A61K31/519
- IPC: A61K31/519 ; C07D487/04 ; A61K45/06 ; A61P25/28 ; A61P25/18

Abstract:
The invention relates to novel 6-Cycloalkyl-pyrazolopyrimidinones according to formula (I). wherein R1 is a 5 or 6 membered aromatic heteroaryl-group, R2 is an optional substituent, D is optionally substituted cyclopentyl, cyclohexyl, tetrahydrofuranyl, tetrahydropyranyl or 2-, 3- or 4-pyridyl, m=1 or 2 and n is 0, 1 or 2. The new compounds are for use as the active entity of medicaments or for the manufacture of medicaments respectively, in particular medicaments for the treatment of conditions concerning deficits in perception, concentration, learning or memory. Such conditions may for example be associated with Alzheimer's disease, schizophrenia and other diseases. The new compounds are also for example for the manufacture of medicaments and/or for use in the treatment of these diseases, in particular for cognitive impairment associated with such disease. The compounds of the invention show PDE9 inhibiting properties.
Public/Granted literature
- US20150025088A1 6-CYCLOALKYL-PYRAZOLOPYRIMIDINONES FOR THE TREATMENT OF CNS DISORDERS Public/Granted day:2015-01-22
Information query
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