Invention Grant
- Patent Title: Rotenone derivatives and a use thereof
- Patent Title (中): 鱼藤酮衍生物及其用途
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Application No.: US14693795Application Date: 2015-04-22
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Publication No.: US09328123B2Publication Date: 2016-05-03
- Inventor: Byung Yeoup Chung , Tae Hoon Kim , Seung Sik Lee , Hyoungwoo Bai , Sungbeom Lee , Chul Hong Park
- Applicant: Korea Atomic Energy Research Institute
- Applicant Address: KR Daejeon
- Assignee: Korea Atomic Energy Research Institute
- Current Assignee: Korea Atomic Energy Research Institute
- Current Assignee Address: KR Daejeon
- Agency: Lathrop & Gage LLP
- Priority: KR10-2012-0118392 20121024
- Main IPC: C07D493/22
- IPC: C07D493/22 ; A61K31/537 ; C07D493/14 ; C07D493/20 ; B01J19/08
Abstract:
The present invention relates to rotenone derivatives and a use of the same. Particularly, the present inventors identified rotenoisin A and B which are compounds with no toxicity and which are prepared by irradiation with gamma rays onto rotenone as represented by the following formula 1. It was further confirmed that the rotenone derivatives significantly inhibited pancreatic lipase activity and preadipocyte differentiation. The rotenone derivatives of the present invention can be effectively used as a composition for the prevention and treatment of obesity and as a composition for health functional food for the prevention and improvement of obesity: (In formula 1, R1 and R2 are as defined in this description).
Public/Granted literature
- US20150225416A1 Novel Rotenone Derivatives and a Use Thereof Public/Granted day:2015-08-13
Information query
