Invention Grant
US09328130B2 Method of treating organism by biologically active compounds specifically delivered into mitochondria, pharmaceutical composition required for the use of the method and a compound applicable for this purpose
有权
通过特异性递送至线粒体的生物活性化合物治疗生物体的方法，使用该方法所需的药物组合物和适用于该目的的化合物
- Patent Title: Method of treating organism by biologically active compounds specifically delivered into mitochondria, pharmaceutical composition required for the use of the method and a compound applicable for this purpose
- Patent Title (中): 通过特异性递送至线粒体的生物活性化合物治疗生物体的方法，使用该方法所需的药物组合物和适用于该目的的化合物
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Application No.: US11972437Application Date: 2008-01-10
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Publication No.: US09328130B2Publication Date: 2016-05-03
- Inventor: Vladimir Petrovich Skulachev
- Applicant: Vladimir Petrovich Skulachev
- Applicant Address: LU Luxembourg
- Assignee: MITOTECH S.A.
- Current Assignee: MITOTECH S.A.
- Current Assignee Address: LU Luxembourg
- Agency: Verrill Dana LLP
- Agent Wayne A. Keown
- Priority: RU2005132217 20051018
- Main IPC: A01N57/00
- IPC: A01N57/00 ; A61K31/66 ; C07D311/82 ; C07F9/54 ; A61K47/48
Abstract:
This invention relates to biology and medicine and, in particular, can be used in medicine to make a pharmaceutical composition for targeted delivery of biologically active substances into mitochondria, driven by proton electro-chemical potential in the mitochondria. This invention also relates to the method to affect an organism by the targeted delivery of biologically active compounds to mitochondria. The invention can be useful in treatment of diseases or disorders associated with not normal functioning of mitochondria, in particular diseases associated with increased production of free radicals and reactive oxygen species.
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