Invention Grant
- Patent Title: Anti-CDH3 antibody having high internalization capacity
- Patent Title (中): 具有高内化能力的抗CDH3抗体
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Application No.: US13882453Application Date: 2011-10-28
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Publication No.: US09328160B2Publication Date: 2016-05-03
- Inventor: Keisuke Ishii , Keiko Katsumi , Tadashi Matsuura , Yukio Sudo , Katsuyuki Mitomo , Katsushi Kouda
- Applicant: Keisuke Ishii , Keiko Katsumi , Tadashi Matsuura , Yukio Sudo , Katsuyuki Mitomo , Katsushi Kouda
- Applicant Address: JP Tokyo
- Assignee: PERSEUS PROTEOMICS INC.
- Current Assignee: PERSEUS PROTEOMICS INC.
- Current Assignee Address: JP Tokyo
- Agency: Birch, Stewart, Kolasch & Birch, LLP
- Priority: JP2010-243708 20101029; JP2011-150812 20110707
- International Application: PCT/JP2011/074958 WO 20111028
- International Announcement: WO2012/057328 WO 20120503
- Main IPC: C07K16/28
- IPC: C07K16/28 ; C12N15/13 ; C07K16/00 ; C07K16/18 ; A61K47/48 ; A61K39/00
Abstract:
It is an object of the present invention to provide an anti-cadherin antibody having a high internalization capacity and provide an anti-cadherin antibody-drug conjugate that effectively kills cadherin-expressing cancer cells with the use of such antibody. The present invention provides an anti-cadherin antibody which recognizes a cadherin domain 1 (EC1) of cadherin and exhibits a high internalization capacity.
Public/Granted literature
- US20130317201A1 ANTI-CDH3 ANTIBODY HAVING HIGH INTERNALIZATION CAPACITY Public/Granted day:2013-11-28
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