Invention Grant
- Patent Title: Anti-human TSLP receptor antibody
- Patent Title (中): 抗人TSLP受体抗体
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Application No.: US14927007Application Date: 2015-10-29
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Publication No.: US09328171B2Publication Date: 2016-05-03
- Inventor: Hiromu Sato , Daisuke Yamajuku , Kazunori Arai , Mako Ogino
- Applicant: Astellas Pharma Inc.
- Applicant Address: JP Tokyo
- Assignee: Astellas Pharma Inc.
- Current Assignee: Astellas Pharma Inc.
- Current Assignee Address: JP Tokyo
- Agency: Oblon, McClelland, Maier & Neustadt, L.L.P.
- Priority: JP2013-165676 20130809
- Main IPC: C12N5/07
- IPC: C12N5/07 ; C12N5/00 ; C12P21/06 ; C07H21/04 ; C07K16/00 ; C07K16/28 ; C07K14/715 ; C12P21/02 ; C07K16/24 ; A61K39/00

Abstract:
[Problem] To provide an anti-human TSLP receptor antibody that specifically binds to human TSLP receptor and inhibits an action of human TSLP through human TSLP receptor.[Means for Solution] An anti-human TSLP receptor antibody had been studied by the present inventors, and an anti-human TSLP receptor antibody comprising a heavy chain variable region consisting of the amino acid sequence of amino acid numbers 1 to 118 of SEQ ID NO: 1 and a light chain variable region consisting of the amino acid sequence of amino acid numbers 1 to 108 of SEQ ID NO: 3 was provided. It was revealed that the anti-human TSLP receptor antibody inhibits expression of TARC mRNA induced by TSLP and production of MDC proteins, and suppressed an allergic reaction in a monkey Ascaris antigen sensitization model, and then the present invention was completed.
Public/Granted literature
- US20160046720A1 NOVEL ANTI-HUMAN TSLP RECEPTOR ANTIBODY Public/Granted day:2016-02-18
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