Invention Grant
- Patent Title: Compositions of asymmetric interfering RNA and uses thereof
- Patent Title (中): 不对称干扰RNA的组成及其用途
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Application No.: US12199797Application Date: 2008-08-27
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Publication No.: US09328345B2Publication Date: 2016-05-03
- Inventor: Chiang Jia Li , Xiangao Sun , Harry Rogoff , Youzhi Li
- Applicant: Chiang Jia Li , Xiangao Sun , Harry Rogoff , Youzhi Li
- Applicant Address: US MA Norwood
- Assignee: 1 GLOBE HEALTH INSTITUTE LLC
- Current Assignee: 1 GLOBE HEALTH INSTITUTE LLC
- Current Assignee Address: US MA Norwood
- Agency: Arent Fox LLP
- Main IPC: A61K48/00
- IPC: A61K48/00 ; C12N15/63 ; C12N15/11
Abstract:
The present invention provides asymmetrical duplex RNA molecules that are capable of effecting sequence-specific gene silencing. The RNA molecule comprises a first strand and a second strand. The first strand is longer than the second strand. The RNA molecule comprises a double-stranded region formed by the first strand and the second strand, and two ends independently selected from the group consisting of 5′-overhang, 3′-overhang, and blunt end. The RNA molecules of the present invention can be used as research tools and/or therapeutics.
Public/Granted literature
- US20090208564A1 Compositions of asymmetric interfering RNA and uses thereof Public/Granted day:2009-08-20
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