Invention Grant
US09328363B2 Genetically engineered Yarrowia lipolytica with enhanced extracellular secretion of α-ketoglutarate
有权
遗传工程解脂耶氏酵母，具有增强的α-酮戊二酸的细胞外分泌
- Patent Title: Genetically engineered Yarrowia lipolytica with enhanced extracellular secretion of α-ketoglutarate
- Patent Title (中): 遗传工程解脂耶氏酵母，具有增强的α-酮戊二酸的细胞外分泌
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Application No.: US14142897Application Date: 2013-12-29
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Publication No.: US09328363B2Publication Date: 2016-05-03
- Inventor: Jian Chen , Jingwen Zhou , Hongwei Guo , Guocheng Du
- Applicant: Jian Chen , Jingwen Zhou , Hongwei Guo , Guocheng Du
- Applicant Address: CN Wuxi, JS
- Assignee: Jiangnan University
- Current Assignee: Jiangnan University
- Current Assignee Address: CN Wuxi, JS
- Agent Lili Chen
- Priority: CN201310481832 20131015
- Main IPC: C12N15/74
- IPC: C12N15/74 ; C12N1/20 ; C12P7/50 ; C07K14/39 ; C12N15/81 ; C12N1/16
Abstract:
The present invention provides four keto acid transporter encoding sequences selected from 6611 protein coding sequences of Yarrowia lipolytica CLIB122 database. Also provided are recombinant Yarrowia lipolytica strains overexpressing the keto acid transporters, which have increased extracellular secretion of α-ketoglutarate. The present invention can be used to increase extracellular levels of α-ketoglutarate during the fermentation process and lower downstream purification cost for α-ketoglutarate production.
Public/Granted literature
- US20150104794A1 Genetically Engineered Yarrowia Lipolytica with Enhanced Extracellular Secretion of a-ketoglutarate Public/Granted day:2015-04-16
Information query
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