A fuel supply structure of a saddle-ride type vehicle wherein a wrong operation of a hose locking member is more securely prevented during maintenance of the vehicle to enhance the maintainability without increasing the number of parts. Fuel supplied from a fuel tank to a throttle body is supplied via fuel supply parts through a flexible fuel hose. A cover member for covering the fuel supply parts is provided. The cover member is provided with a cover that covers a fuel hose locking member for locking the connection of the fuel hose and each fuel supply part. In addition, the cover covers the fuel hose locking member to disenable removing the fuel hose locking member.