Invention Grant
- Patent Title: Vivo isotopic labeling method for quantitative glycomics
- Patent Title (中): 用于定量糖基化的体内同位素标记方法
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Application No.: US12734102Application Date: 2008-10-29
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Publication No.: US09329169B2Publication Date: 2016-05-03
- Inventor: Robert Lance Wells , Ronald C. Orlando , Stephen Dalton , Kelley W. Moremen , James Michael Pierce , James A. Atwood, III , Michael Tiemeyer , William S. York
- Applicant: Robert Lance Wells , Ronald C. Orlando , Stephen Dalton , Kelley W. Moremen , James Michael Pierce , James A. Atwood, III , Michael Tiemeyer , William S. York
- Applicant Address: US GA Athens
- Assignee: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC
- Current Assignee: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC
- Current Assignee Address: US GA Athens
- Agent Henry D. Coleman; R. Neil Sudol
- International Application: PCT/US2008/012283 WO 20081029
- International Announcement: WO2009/058307 WO 20090507
- Main IPC: C12Q1/02
- IPC: C12Q1/02 ; G01N33/50 ; G01N33/68
Abstract:
The present invention relates to a method of isotopically labeling glycans and in facilitating high throughput quantitative/comparative analysis of glycomic compositions of biological cells. The method is applicable inter alia for identifying differentiated cells and their glycomic characteristics, differentiation conditions, disease and/or therapeutic progression, diagnosing disease states, determining drug activity, establishing manufacturing efficiencies and for determining the half-life of glycans in cells.
Public/Granted literature
- US20100297609A1 VIVO ISOTOPIC LABELING METHOD FOR QUANTITATIVE GLYCOMICS Public/Granted day:2010-11-25
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