A method of high-resolution ultrasound imaging, in which transducers are made to emit ultrasound waves in a field of observations containing micro bubbles, by making the micro bubbles burst one by one in tandem with the emissions of ultrasound waves. At each shot j of an ultrasound wave, raw reverberated signals Sj(i,t) picked up by each transducer i are recorded, and then differential signals Vj(i,t) representative of variations between successive raw signals are determined, a parabolic function Pj(x) is fitted to the differential signals corresponding to each shot j, and then a crest Aj(x0,y0) of this function Pj, corresponding to the position of the micro bubble destroyed between shots j−1 and j, is determined.