Systems and methods for enhancing performance in a multithreaded computing system are provided. The method comprises receiving a plurality of values associated with a performance characteristic common to a plurality of threads; clusterizing the plurality of threads based on the performance characteristic; analyzing an inter-thread communication between the plurality of threads for identifying a plurality of threads adversely affecting the performance of different parts of the multithreaded program; calculating a performance factor corresponding to the performance characteristic to determine a type of performance improvement activity to be performed on the plurality of threads.