A system and method for calibration of serial links using serial-to-parallel loopback. Embodiments of the present invention are operable for calibrating serial links using parallel links thereby reducing the number of links that need calibration. The method includes sending serialized data over a serial interface and receiving parallel data via a parallel interface. The serialized data is looped back via the parallel interface. The method further includes comparing the parallel data and the serialized data for a match thereof and calibrating the serial interface by adjusting the sending of the serialized data until the comparing detects the match. The adjusting of the sending is operable to calibrate the sending of the serialized data over the serial interface.