In an electrophysiology (EP) lab, a bedside interface device allows an EP physician to directly control various diagnostic and therapeutic systems, including an electro-anatomic mapping system. The bedside interface device can include a computer with wireless communication capability as well as a touch-responsive display panel and voice recognition. The bedside interface device can also be a hand-graspable wireless remote control device that is configured to detect motions or gestures made with the remote control by the physician, allowing the physician to directly interact with the mapping system. The bedside interface device can also be a motion capture camera configured to determine motion patterns of the physician's arms, legs, trunk, face and the like, which are defined in advance to correspond to commands for the mapping system. The bedside interface device may also include voice recognition capabilities to allow a physician to directly issue verbal commands to the mapping system.