The present disclosure discloses a system of self-adaptively adjusting Multi-area common voltage, comprising a plurality of photosensitive devices, for sensing luminous quantity from the different areas so as to obtain and transmit flicker values corresponding to the different areas; a multiplexing element, connected with the plurality of photosensitive devices; a calculation and comparison unit, for continuously receiving the flicker values which are sensed by the plurality of photosensitive devices in a time sequence, calculating actual display condition, and comparing the actual display condition with an optimal display condition; and an common voltage adjusting and outputting unit, connected with the calculation and comparison unit, for adjusting the value of the current output common voltage if the optimal display condition is not met and remaining the value of the current output common voltage unchanged if the optimal display condition is met. The present disclosure can achieve automatically adjustment of the common voltage and thus increase the productivity.