A drive circuit of a display panel, a display panel, a display device and a method of driving a display device are provided. The circuit comprises: j select circuits and j data line signal output circuits, j is an integer greater than or equal to 2. Each data line is connected with a select circuit, different data lines are connected with different select circuits, each select circuit is connected with the j data line signal output circuits, each select circuit can control the data line connected therewith to be connected with one of these j data line signal output circuits and to control the data line connected therewith to be disconnected from the other ones of these j data line signal output circuits; so pixels at different locations can be scanned by powering the data lines connected with the pixels using the different data line signal output circuits.