An epidermal friendly twist-on wire connector and a method of applying an epidermal twist-on wire connector having a resilient gripping region including a set of low profile, resilient ribs that are circumferentially spaced so that a users thumb and fingers can compressively and sequentially engage and compress at least a portion of a plurality of ribs as well as the valley between the ribs during application of a wire securement torque to the twist-on wire connector while at the same time inhibiting or preventing epidermal trauma in a users thumb and fingers.