The present invention provides a voltage-application drive system, including a power module, a switching module and a voltage-application module, wherein the switching module including a plurality of switches and the voltage-application module including a plurality of voltage-application units; switching module receiving selection of voltage driver manner from user and controlling the plurality of switches and selectively supplying drive voltage according to the selection of voltage-application drive manner; the voltage-application unit receiving the drive voltage and converting the drive voltage into voltage required by the selection of voltage-application drive manner. As such, the present invention can reduce manufacturing cost, improve production efficiency and improve the flexibility of manufacturing process.