A multiple-user multiple input-multiple output wireless communication system uses a set of multiple subcarriers arranged in plural subsets or resource blocks. Precoding of signals transmitted from a base station to user terminals involves acquiring channel state information on the connection channel between the base station and user terminals in the plurality. Channel quality indicators are detected with user terminals for respective subsets of resource blocks to produce user/resource block pairs having associated channel quality indicators. The user/resource block pairs are subjected to selection as a function of the channel quality indicators associated therewith so that precoding is performed by acquiring channel state information exclusively for the user/resource block pairs surviving the selection as a function of the channel quality indicators and, possibly, other selection steps as a function of other parameters, such as, speed, maximum bit rate, and direction of arrival or angular spread in a multiple-stage selection process.