Methods and apparatus for multiple-input multiple-output (MIMO) transmissions are disclosed. A base station may precode wireless transmit/receive unit (WTRU)-specific reference signals and data that are transmitted to a WTRU using a randomly selected precoder. The precoder may be selected based on a predefined precoder selection sequence or by the base station. A different precoder may be applied to different resource blocks (RBs). In addition, a large delay cyclic delay diversity (CDD) or discrete Fourier transform (DFT) spreading may be applied on the WTRU-specific reference signals and the data. For heterogeneous deployed antennas, spatial diversity gain is achieved by dynamically scheduling resources between transmission points. A hopping scheme may be applied across the transmission points as the resources are dynamically partitioned between the transmission points. A different randomly selected precoder may be applied to each RB transmitted from a different transmission point.