Mechanisms provide hosts such as servers and mobile devices with access to virtualized I/O resources including virtual Host Bus Adapters (vHBAs) and virtual Network Interface Cards (vNICs) over a wireless I/O interconnect. Host applications access virtualized I/O resources using virtual device drivers that communicate with virtualized I/O resources on an I/O director using a reliable communication protocol running over a wireless network. I/O data is throttled if necessary based on wireless network considerations.