A method and apparatus are provided for transmitting and receiving control information in a wireless communication system supporting multi-cell transmission. A method includes receiving a first pilot signal from a first cell and a second pilot signal from a second cell; generating first control information indicating channel quality for the first cell and second control information indicating channel quality for the second cell, based on the first pilot signal and the second pilot signal, respectively; separately encoding the first control information and the second control information; separately power controlling the encoded first control information and the encoded second control information; transmitting, on the first cell, the power controlled, encoded first control information on a first control channel; and transmitting, on the first cell, the power controlled, encoded second control information on a second control channel.