Invention Grant
- Patent Title: Isoxazolo-quinazolines as modulators of protein kinase activity
- Patent Title (中): 异唑并喹唑啉作为蛋白激酶活性的调节剂
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Application No.: US13813200Application Date: 2011-07-20
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Publication No.: US09333205B2Publication Date: 2016-05-10
- Inventor: Marina Caldarelli , Italo Beria , Nicoletta Colombo , Claudia Piutti , Matteo Salsa , Gabriella Traquandi
- Applicant: Marina Caldarelli , Italo Beria , Nicoletta Colombo , Claudia Piutti , Matteo Salsa , Gabriella Traquandi
- Applicant Address: IT Nerviano (MI)
- Assignee: NERVIANO MEDICAL SCIENCES S.R.L.
- Current Assignee: NERVIANO MEDICAL SCIENCES S.R.L.
- Current Assignee Address: IT Nerviano (MI)
- Agency: Scully, Scott, Murphy & Presser, P.C.
- Priority: EP10171375 20100730
- International Application: PCT/EP2011/062453 WO 20110720
- International Announcement: WO2012/013557 WO 20120202
- Main IPC: C07D498/04
- IPC: C07D498/04 ; A61K31/519 ; C07D498/02 ; A61K45/06 ; A61N5/10
Abstract:
The present invention relates to substituted isoxazolo-quinazolines which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular human MPS1 and PERK. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such these compounds or the pharmaceutical compositions containing them.
Public/Granted literature
- US20130143896A1 ISOXAZOLO-QUINAZOLINES AS MODULATORS OF PROTEIN KINASE ACTIVITY Public/Granted day:2013-06-06
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