Invention Grant
US09333239B2 Use of osteoprotegerin (OPG) to increase human pancreatic beta cell survival and proliferation
有权
使用骨保护素（OPG）来增加人胰腺β细胞的存活和增殖
- Patent Title: Use of osteoprotegerin (OPG) to increase human pancreatic beta cell survival and proliferation
- Patent Title (中): 使用骨保护素（OPG）来增加人胰腺β细胞的存活和增殖
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Application No.: US13802159Application Date: 2013-03-13
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Publication No.: US09333239B2Publication Date: 2016-05-10
- Inventor: Rupangi Vasavada , Nagesha Guthalu Kondegowda
- Applicant: University of Pittsburgh—Of the Commonwealth System of Higher Education
- Applicant Address: US PA Pittsburgh
- Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
- Current Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
- Current Assignee Address: US PA Pittsburgh
- Agency: Klarquist Sparkman, LLP
- Main IPC: A61K38/18
- IPC: A61K38/18 ; C07K14/51 ; C07K19/00 ; C12N5/00 ; C12Q1/02 ; A61K38/19 ; A61K45/06 ; A61K38/28
Abstract:
It is disclosed herein that osteoprotegerin increases human beta cell proliferation and survival. Methods are provided for increasing beta cell proliferation, but contacting a beta cell with an effective amount of osteoprotegrin, a functional fragment, variant or fusion protein thereof. Methods are also provided for treating a human subject with diabetes, comprising administering to the subject a therapeutically effective amount of osteoprotegerin, functional variant or fusion protein thereof.
Public/Granted literature
- US20130251668A1 USE OF OSTEOPROTEGERIN (OPG) TO INCREASE HUMAN PANCREATIC BETA CELL SURVIVAL AND PROLIFERATION Public/Granted day:2013-09-26
Information query
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