Invention Grant
- Patent Title: Compounds useful as inhibitors of ATR kinase
- Patent Title (中): 可用作ATR激酶抑制剂的化合物
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Application No.: US13106184Application Date: 2011-05-12
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Publication No.: US09334244B2Publication Date: 2016-05-10
- Inventor: Jean-Damien Charrier , Steven John Durrant , Ronald Marcellus Alphonsus Knegtel , Anisa Nizarali Virani , Philip Michael Reaper
- Applicant: Jean-Damien Charrier , Steven John Durrant , Ronald Marcellus Alphonsus Knegtel , Anisa Nizarali Virani , Philip Michael Reaper
- Applicant Address: US MA Boston
- Assignee: Vertex Pharmaceuticals Incorporated
- Current Assignee: Vertex Pharmaceuticals Incorporated
- Current Assignee Address: US MA Boston
- Agency: Wolf, Greenfield & Sacks, P.C.
- Main IPC: C07D241/06
- IPC: C07D241/06 ; C07D413/04 ; C07D239/46
Abstract:
The present invention relates to pyrazine and pyridine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.The compounds of this invention have formula IV: wherein the variables are as defined herein.
Public/Granted literature
- US20120122884A1 COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE Public/Granted day:2012-05-17
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