Invention Grant
US09334274B2 N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
有权
吡唑-4-基 - 吡咯并[2,3-d]嘧啶和吡咯-3-基 - 吡咯并[2,3-d]嘧啶的N-（杂）芳基 - 吡咯烷衍生物作为甘蔗激酶抑制剂
![N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors](/docs/US/2016-05-10/US09334274B2/abs.jpg.600x600.jpg)
- Patent Title: N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
- Patent Title (中): 吡唑-4-基 - 吡咯并[2,3-d]嘧啶和吡咯-3-基 - 吡咯并[2,3-d]嘧啶的N-（杂）芳基 - 吡咯烷衍生物作为甘蔗激酶抑制剂
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Application No.: US14250843Application Date: 2014-04-11
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Publication No.: US09334274B2Publication Date: 2016-05-10
- Inventor: James D Rodgers , Stacey Shepard , Argyrios G Arvanitis , Haisheng Wang , Louis Storace , Beverly Folmer , Wenyu Zhu , Joseph Glenn , Lixin Shao
- Applicant: Incyte Corporation , Incyte Holdings Corporation
- Applicant Address: US DE Wilmington US DE Wilmington
- Assignee: Incyte Holdings Corporation,Incyte Corporation
- Current Assignee: Incyte Holdings Corporation,Incyte Corporation
- Current Assignee Address: US DE Wilmington US DE Wilmington
- Agency: Fish & Richardson P.C.
- Main IPC: A01N43/90
- IPC: A01N43/90 ; A61K31/519 ; C07D487/00 ; C07D487/04 ; C07D519/00 ; C07D471/04 ; C07D491/048 ; C07D495/04 ; C07D498/04 ; C07D513/04
![N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors](/abs-image/US/2016/05/10/US09334274B2/abs.jpg.150x150.jpg)
Abstract:
The present invention relates to N-(hetero)aryl-pyrrolidine derivatives of Formula I: which are JAK inhibitors, such as selective JAK1 inhibitors, useful in the treatment of JAK-associated diseases including, for example, inflammatory and autoimmune disorders, as well as cancer.
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