Invention Grant
- Patent Title: Method of reducing recurrence of multiple sclerosis symptoms in a mammal by administering an anti-repulsive guidance molecule neutralizing antibody
- Patent Title (中): 通过施用抗排斥性指导分子中和抗体来减少哺乳动物多发性硬化症状复发的方法
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Application No.: US13514915Application Date: 2010-12-08
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Publication No.: US09334323B2Publication Date: 2016-05-10
- Inventor: Toshihide Yamashita , Takekazu Kubo
- Applicant: Toshihide Yamashita , Takekazu Kubo
- Applicant Address: JP Osaka
- Assignee: Mitsubishi Tanabe Pharma Corporation
- Current Assignee: Mitsubishi Tanabe Pharma Corporation
- Current Assignee Address: JP Osaka
- Agency: Leydig, Voit & Mayer, Ltd.
- Priority: JP2009-279189 20091209
- International Application: PCT/JP2010/071965 WO 20101208
- International Announcement: WO2011/071059 WO 20110616
- Main IPC: A61K38/16
- IPC: A61K38/16 ; C07K16/28 ; A61K31/07 ; A61K31/122 ; A61K31/355 ; A61K31/375 ; A61K33/00 ; A61K33/04 ; A61K33/06 ; A61K33/26 ; A61K33/30 ; C07K16/18
Abstract:
Provided is a T cell activation inhibitor containing an RGM inhibiting substance such as an anti-RGM neutralizing antibody and the like as an active ingredient. The T cell activation inhibitor is useful as a pharmaceutical composition for the prophylaxis or treatment of autoimmune diseases such as multiple sclerosis and the like, and other diseases caused by T cell activation. In addition, a T cell activation inhibiting substance can be screened for by contacting a test substance with RGM and selecting a test substance that lowers the activity level of RGM.
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